A neutron source for the study of biological objects formed from superficially touching cones made of borated spheroplastics
https://doi.org/10.17073/1609-3577j.met202308.519
Abstract
At the Prometheus medical accelerator with a proton beam energy of 225 MeV, a source of fast and epithermal neutrons was constructed and measurements of neutron dose profiles at the output of the neutron channel were carried out using the BDMN-100 detector. A heavy NaI target was used to produce fast neutrons. Together with the research laboratory of the Central Laboratory of Avangard JSC, a new protective material against neutrons called wikineutron was developed, with a different percentage of 10B. This new material has been studied many times at the Prometheus proton accelerator and the Pakhra electron accelerator. Based on the developed new protective materials against neutrons, a shadow protection was formed, made in the form of surface contacting cones, forming a channel of fast and epithermal neutrons. Fast neutrons can be used for remote therapy. Also, a neutron beam can be used to study biological objects and cells. It is also possible to use a neutron source from the Prometheus accelerator for the treatment of superficial tumors. The developed neutron channel can be used for medical work on the creation of new radiopharmaceuticals containing boron and other highly absorbing elements. The developed neutron source is a compact low-power source of therapeutic neutrons, which can be used for the treatment of superficial types of cancer. The main goal of the work was: the formation, based on the developed neutron-absorbing materials, of a neutron channel, which has a simple design and can be used for boron-neutron capture therapy and nadepithermal therapy; creation on the neutron channel of a beam of epithermal neutrons and supra-epithermal neutrons to assess the effectiveness of the use of radiopharmaceuticals.
The developed neutron-absorbing materials made it possible to create a neutron channel of epithermal neutrons and supra-epithermal neutrons for therapy and the development of gold-based radiosensitizers.
Keywords
About the Author
V. V. SiksinRussian Federation
53 Leninsky Ave., Moscow 119991
Viktor V. Siksin — Cand. Sci. (Phys.-Math.), Senior Researcher
References
1. Zaidi L., Kashaeva E.A., Malyshkin G.N., Samarin S.I., Frolov S.A., Lezhnin S.I., Taskaev S.Y., Sycheva T.V. Neutron-beam-shaping assembly for boron neutron-capture therapy. Physics of Atomic Nuclei. 2017; 80(1): 60—66. https://doi.org/10.1134/S106377881701015X
2. Butterworth K.T., McMahon S.J., Currell F.J., Prise K.M. Physical basis and biological mechanisms of gold nanoparticle radiosensitization. Nanoscale. 2012; 4(16): 4830—4838. https://doi.org/10.1039/c2nr31227a
3. Hubbell J.H., Seltzer S.M. Tables of x-ray mass attenuation coefficients and mass energy-absorption coefficients 1 keV to 20 MeV for elements Z = 1 to 92 and 48 additional substances of dosimetry interest. Radiation Physics Division, PML, NIST; 1996. https://dx.doi.org/10.18434/T4D01F
4. Cui L., Her S., Borst G.R., Bristow R.G., Jaffray D.A., Allen Ch. Radiosensitization by gold nanoparticles: will they ever make it to the clinic? Radiotherapy and Oncology. 2017; 124(3): 344—356. https://doi.org/10.1016/j.radonc.2017.07.007
5. Gerosa C., Crisponi G., Nurchi V.M., Saba L., Cappai R., Cau F., Faa G., Van Eyken P., Scartozzi M., Floris G., Fanni D. Gold nanoparticles: a new golden era in oncology? Pharmaceuticals. 2020; 13(8): 192. https://doi.org/10.3390/ph13080192
6. Dan Jones T.L., Fast neutron therapy. http://www.canberra.edu.au/IRPS/archives/ vol15no2/mempap.html
7. Dan Jones T.L., Fast neutron therapy. https://www.canberra.edu.au/irps/bulletin/1996-2005/docs/15-2.pdf
8. Musabaeva L.I. (ed.). Fast neutrons in oncology. Tomsk: Izdatel'stvo nauchno-tekhnicheskoi literatury; 2000. 188 p. (In Russ.)
9. Musabaeva L.I., Golovkov V.М. Fast neutron therapy for cancer patients. Sibirskij onkologičeskij žurnal. 2015; (2): 88—94. (In Russ.)
10. Pat. (RU) No 2009914832. IPC A61N5/10, G01N23/05, G21K1/02. Borisov G.I., Erak D.Yu. Device for the treatment of oncological diseases. Appl.: 12.2.2009; publ.: 07.27.2011. (In Russ.). https://www.freepatent.ru/patents/2424832
11. Ivanov V.K. Possibilities and prospects of mathematical modeling in radiation therapy. Meditsinskaya radiologiya = The Medical Radiology. 1985; 30(3): 67. (In Russ.)
12. Magdon E. Relative biological activity of neutrons with an energy of 6.2 meV. Meditsinskaya radiologiya = The Medical Radiology. 1977; 22(10): 40—42. (In Russ.).
13. Borisov G.I., Kumakhov M.A., Kondratenko R.I. Calculation estimates of the possibility of implementing invasive neutron capture therapy using capillary neutron-optical systems. Rossiiskii bioterapevticheskii zhurnal = Russian Journal of Biotherapy. 2006; (1): 34. (In Russ.)
14. Kurachenko Yu.A., Kazansky Yu.A., Matusevich Eu.S. Subcritical systems for neutron capture therapy. Izvestiya vuzov. Yadernaya energetika. 2008; (3): 47—56. (In Russ.)
15. Malutin E.V., Siksin V.V., Shemyakov A.E., Sgegolev I.Ju. Protective properties of the РОV-40 material under conditions of irradiation with secondary neutrons and gamma rays. Medical Physics. 2019; (4(84)): 75—79. (In Russ.)
16. Shirokov M., Yudin N.P. Nuclear physics. Мoscow: Nauka; 1980. 728 p. (In Russ.)
17. Kononov O.E. Neutron sources based on accelerators for neutron and neutron capture therapy problems. Summary Diss. Cand. Sci. (Phys.-Math.); 2010. 106 p. (In Russ.)
Review
For citations:
Siksin V.V. A neutron source for the study of biological objects formed from superficially touching cones made of borated spheroplastics. Izvestiya Vysshikh Uchebnykh Zavedenii. Materialy Elektronnoi Tekhniki = Materials of Electronics Engineering. 2023;26(3):248-255. (In Russ.) https://doi.org/10.17073/1609-3577j.met202308.519