Formation of a mixed source of epithelial neutrons and a scanning proton beam at Prometheus CРT for the treatment of tumors in flash therapy mode
https://doi.org/10.17073/1609-3577j.met202406.596
Abstract
On a medical accelerator “Prometheus“ at an energy of 200 MeV, a mixed secondary beam of delayed neutrons and a scanning high-intensity pencil beam of protons were designed to irradiate the tumor in flash therapy mode with a dose of 50–70 Gray. A neutron-forming target was used to produce fast neutrons and then delayed neutrons. The special design of the neutron-producing target allowed for several pulses of the accelerator to irradiate the outer surface of the tumor with scanning spots of protons and simultaneously irradiate the entire tumor area with delayed neutrons. Using the developed new composites for neutron protection, a mixed beam channel was constructed: delayed neutrons and scanning proton spots. The power profiles of the equivalent dose at the outlet of the channel for the neutron component of the channel were measured using an ionization pad chamber on a “warm liquid”. The pencil proton beam, scanning the entire outer surface of the tumor and sequentially changing the scanning depth, should destroy the superficial blood vessels on the outer surface of the tumor. The average radiation dose per session should be 50–70 Gray. A neutron beam simultaneously with protons during a flash therapy session irradiates the entire tumor area and has a combined value, working in the mode of the neutron capture dose-forming component of this treatment method, in the presence of the introduction of the desired sensitizer. It is proposed to enhance the effect of a proton beam scanning the tumor surface, due to additional dose generation from radio sensitizers based on nano-gold particles.
Keywords
Supporting agencies: The work was carried out with the financial support of the Ministry of Education and Science of Russia under Agreement No. 075-15-202.
About the Authors
V. V. Siksin
Lebedev Physical Institute of the Russian Academy of Sciences
Russian Federation
Russian Federation
53 Leninsky Ave., Moscow 119991
Viktor V. Siksin — Cand. Sci. (Phys.-Math.), Senior Researcher
I. Yu. Shchegolev
Avangard JSC
Russian Federation
Russian Federation
78 Oktyabrskaya Str., Safonovo, Smolensk Region 215500
Igor Yu. Shchegolev — Head of the TSL Product Quality Research Sector
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Review
For citations:
Siksin V.V., Shchegolev I.Yu. Formation of a mixed source of epithelial neutrons and a scanning proton beam at Prometheus CРT for the treatment of tumors in flash therapy mode. Izvestiya Vysshikh Uchebnykh Zavedenii. Materialy Elektronnoi Tekhniki = Materials of Electronics Engineering. 2024;27(4):358-368. (In Russ.) https://doi.org/10.17073/1609-3577j.met202406.596
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