Application of methods investigation of materials and structures of electronics in development of medical titanium endoprostheses with increased fibrointegration efficiency

Titanium alloys approved for clinical use in our country are widely used in traumatology, maxillofacial surgery and stomatology, mainly for the manufacture of various endoprostheses and dental implants, i.e. structures, introduced and installed in the bone and soft tissues of human body, able to both bio-integrate and bio-adaptable in the tissues of human body. 
In the field of medical materials science and in particular in the development of medical products based on titanium and its alloys and various coatings on the surface of such products, modern methods and modern equipment developed for the electronics industry are successfully used.
In this paper, the methods of research of materials and structures of electronics used in the field of medical technology and specifically in the development of medical titanium endoprostheses have made it possible to develop the basics of the technology for obtaining optimal microrelief on the surface of titanium endoprostheses intended for engraftment in soft tissues (i.e. fibrointegrable) with bioactive coating of titanium dioxide TiO₂ with an anatase structure obtained by atomic-layer deposition. The research aimed at revealing the optimal surface treatment of such endoprostheses in order to achieve improved fibrointegration properties in their use in maxillofacial surgery has been carried out.
It has been shown that high adhesion and fibrointegration between the titanium endoprosthesis and connective tissue are achieved with an average surface roughness (4—8)⋅10² nm, root-mean-square roughness 5⋅10²—1⋅10³ nm, profile height (3—6)⋅10³ nm, and thickness bioactive coating in the order of 10 nm.

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